- Inflammation is a natural response of the human body to tissue injury or infection, but can, in some normal and abnormal conditions, be acute or chronic and result in serious complications, including colon cancer. The various checks and balances within the inflammatory process may be compromised by the quantity and duration of the insult, or by a host of genetic and environmental factors including diet. Several epidemiological and pre-clinical studies reveal that specific bioactive food components can suppress colonic inflammation as well as reduce colon cancer risk. Nevertheless, it remains unclear whether these diet-induced shifts in the inflammatory process account for their anti-tumorigenic properties in colon cancer. This PA is designed to foster innovative research that will identify and characterize diet-induced changes in inflammation and colon cancer risk.
- Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the numbers, qualities, durations, and costs of the applications received.
- This funding opportunity will use the NIH investigator-initiated research project grants (R01) and exploratory/developmental (R21) award mechanisms.
- You may submit (an) application(s) if your institution has any of the following characteristics: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of State and local governments; eligible agencies of the Federal government; domestic institutions; foreign institutions; faith-based or community-based organizations; Units of State Tribal government; and Units of Local Tribal government.
- Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.
- See Section IV.1 for application materials.
- Applicants may submit more than one application, provided they are scientifically distinct.
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088.
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Cancer Biology Research
Cancer Cause and Prevention Research
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